Category: Family
Combination of Liquid Biopsy Tools Improves Results in Detecting Biomarkers, May Lead to Better Selection of Targeted Mesothelioma Treatments
Researchers continue to look for an effective tool that can be used for the early detection of cancer and to track the effectiveness of treatment. Now, one company reports that by pairing its liquid biopsy analyzer tool with another company’s genetic data analysis tool, the resulting tests proved to be nearly 100% accurate. This is another step in using blood tests to help guide personalized medicine for lung cancer and pleural mesothelioma patients.
In a press release prior to the Fifth AACR-IASLC International Joint Conference held earlier this month in San Diego, Biocept, Inc, reports when it paired the Target Selector ctDNA lung cancer assays with the Thermo Fisher QuantStudio5 (QS5) real-time PCR instrument results of the detection of key lung cancer mutations resulted in “more than 99% sensitivity and more than 99% specificity.”
“The ability to rapidly and accurately assess the molecular status of a patient’s tumor using a simple blood draw can be a critical factor in the selection of individualized targeted therapy,” said Biocept’s Senior Vice President and Senior Medical Director Veena Singh, MD. “Our tests can further provide for the monitoring of response to therapy over time without invasive tissue biopsies that can be difficult to perform in patients diagnosed with cancer.”
The tests targeted EGFR, KRAS and BRAF mutations that have been shown to be present in lung cancer and in some pleural mesothelioma tumors as well. According to some reports, mutations of the KRAS gene (Kirsten rat sarcoma viral oncogene homolog) are found in 20 to 25 percent of lung cancers. The EGFR gene is overexpressed in more than 50% of pleural mesothelioma patients, and in approximately 15% of lung cancer patients, and is one of the primary targets for bringing personalized care to cancer patients.
With the advent of personalized therapies that target specific biomarkers, ensuring that effective tools are available to quickly and easily identify treatable mesothelioma markers is critical. Personalized cancer treatment optimizes the potential for success.
Often, lung cancer and mesothelioma patients must undergo invasive and painful biopsies to extract diseased tissue for diagnosis. Tissue biopsy tests can take up to 10 days to get a result leaving patients worried and missing out on treatment. However, with just a blood sample, this partnership could bring effective treatments to cancer patients in a shorter time.
Pleural mesothelioma, caused by exposure to airborne asbestos fibers, is an incurable cancer involving the lining of the lung. Nearly 3,000 Americans are diagnosed with mesothelioma each year. There is no cure for the cancer.
Libby, Montana Mesothelioma Doctors Contribute Knowledge to Medical Journals
The doctors at Libby, Montana’s Center for Asbestos Related Disease (CARD) know a thing or two about mesothelioma. The town is home to a vermiculite mine blamed for widespread contamination from asbestos exposure and for hundreds of cases of mesothelioma, and CARD has been the hub for care and screening of many of the patients. Now, the medical team is sharing their knowledge of this deadly disease through collaboration on articles for scientific journals.
Dr. Brad Black and Dr. Gregory Loewen, both physicians at CARD, were among the authors in two separate studies published recently in the peer-reviewed journals Inhalation Toxicology and the Journal of Occupational and Environmental Medicine (JOEM), according to a Dec. 29 article in The Western News. The two provided their expertise into the studies looking at the pulmonary function of miners at Libby’s vermiculite mine.
In the study of 256 individuals who worked at the mine for a minimum of six months, the researchers concluded “eighty-seven percent of miners exposed to Libby Amphibole had pleural abnormalities on CT [computed tomography].” The study was published in JOEM.
“… most doctors probably don’t know about this unique type of asbestos related disease and wouldn’t be able to recognize it in their patients if they didn’t hear about it,” said Dr. Black on why the study is important.
The W.R. Grace vermiculite mine and mill located in Libby, closed since 1990, was found to have an asbestos deposit in the mine and is the site of significant asbestos exposure. According to reports, nearly 3,000 residents and former miners have been diagnosed with an asbestos-related disease, and over 400 have died from mesothelioma. Contamination from the site led the federal government to declare Libby a health emergency.
Asbestos is a known carcinogen and is proven to cause mesothelioma, a serious cancer caused by breathing in the asbestos fibers that then become lodged in the thin membrane that lines and encases the lungs.
The second study followed one individual who worked at the mine from 1969 to 1990 and had no other known exposure to asbestos. The person developed “asbestos-like” pathological features and eventually an adenocarcinoma. According to the authors, “This is to our knowledge the first time such an extensive evaluation has been conducted in a vermiculite miner from Libby, Montana.”
About CARD
CARD’s primary goal is to provide specialty healthcare and screening to those affected by Libby Amphibole Asbestos. CARD’s secondary goal is to stimulate research from around the country to gain further understanding of disease mechanisms, improve early disease and cancer detection and intervention, and develop effective health management strategies in hope of finding answers to improve health outcomes for individuals and communities.
Find out more about the Center for Asbestos Related Disease on its website.
Read the studies in the Dec. 1 issue of the Journal of Occupational and Environmental Medicine and in the Oct. 17 issue of Inhalation Toxicology.
Sources:
- Center for Asbestos Related Disease
http://www.libbyasbestos.org/ - Inhalation Toxicology
http://www.tandfonline.com/doi/abs/10.1080/08958378.2017.1372536 - Journal of Occupational and Environmental Medicine
http://journals.lww.com/joem/pages/default.aspx
- The Western News
http://www.thewesternnews.com/front_page_slider/20171229/libby_asbestos_clinic_contributes_research_to_two_journals
Make the Most of the New Year
During the holidays, “Happy New Year!” gets repeated countless times throughout the day. Whether it is from the barista at the local coffee shop or the staff at the medical center, this is not the message a mesothelioma patient or his or her family wants to hear. It is doubtful that anyone with mesothelioma is happy.
But today is the start of a new year, and mesothelioma patients and their families can make the most of every day. In 2018, consider looking at “happy” another way and change the way you look at the new year.
Help others in the mesothelioma community by offering them insights from your experiences.
Always stay positive.
Praise your caregivers and let them know they are appreciated and valued.
Take Pleasure in the little things and look forward to whatever the next day may bring.
Your medical team members are your partners and advocates. Insist on the best care from them, and make sure they know what you want.
Just like looking at “happy” one letter at a time may help you change your perspective, take 2018 one day at a time and make the most of the new year.
In the New Year: Moving On And Growing While Honoring Dad
This time of year is beautiful for so many reasons; the birth of Jesus being celebrated, time being spent with cherished family and friends, the snowy weather, I could go on and on about things I love about Christmastime. On the other hand, it’s a tough time when you are mourning the loss of a loved one. No matter how much time passes, it’s always a hard season for me without my Dad being here.
Just last night, I saw this picture of my father dressed as Santa. Every year for his Church Christmas party, he would emerge dressed as the big man in red. Even though he sometimes gave himself away (he would forget to change his boots and take off his watch almost every time!), you could see how happy he was listening to the children tell him about their year and how good they’ve been… even though sometimes, a child would be brutally honest with him, saying that they fell a bit short of the nice list.
When I saw that picture, I cried. I cried because this particular snapshot was from his last Christmas. I cried because I feel like my daughter has been cheated by not getting a chance to experience this tradition with him. I cried because no matter how old I get, I’ll always need my Dad. I cried because I don’t like change, and this change was one that I never could have seen coming.
Even though it is difficult, my family decides to carry on. Not just for my daughter, but for Dad. He loved Christmas and would want us to continue our traditions, as well as to make new ones together. Just because there are new things added, it doesn’t take away from the value of the old.
This is a great message for the New Year! Moving forward doesn’t have to mean leaving things behind. Growing doesn’t mean that you overlook the process that got you to where you are. Carrying on does not equal forgetting the past. It is a new year, a whole year of possibilities awaits you. So dive in, enjoy this time that God has given you, but don’t forget to reflect on years past, and smile at all of your treasured memories.
Your Presence is the Perfect Present For Mesothelioma Patients
This time of year everyone is rushing around hoping to make the holidays perfect. While that means something different to everyone – decorations, gifts, lots of food, or chocolaty desserts – for those suffering from mesothelioma it may just mean having their loved ones close by their side.
During the holiday season, feelings of sadness, loneliness and anxiety about an uncertain future for mesothelioma patients and their families are often accentuated leaving them depressed and overwhelmed. One thing that could lift your mood, and is within your control, is to simply take the time to revel in the enjoyment of your family and friends. Jennifer Gelsick, a “Faces of Mesothelioma” author, said on Friday that her father’s presence was the best present she had at Christmas, and just having his family home for the holidays buoyed her father’s spirits.
If you have a friend or a loved one who is sick over the holidays and you are not able to visit them, take the time to send a hand-written card or make a phone call to let them know you are thinking of them. In this day of technology, a personal touch can go a long way towards brightening someone’s day.
Sit back and try to enjoy the enjoy the simple pleasures of the holidays: the lights of the season, a light snow falling, a football game on TV, a fire in the fireplace or the bite of a delicious cookie. And, especially, the company of your family and friends. Remember that it is your presence that is the best present!
Happy holidays from all of us at MesotheliomaHelp.
Free Mesothelioma Patient & Treatment Guide
We’d like to offer you our in-depth guide, “A Patient’s Guide to Mesothelioma,” absolutely free of charge.
It contains a wealth of information and resources to help you better understand the condition, choose (and afford) appropriate treatment, and exercise your legal right to compensation.
Download Now